Today I will review a lecture given by Jon Pangborn, Ph.D. at the 2008 DAN! conference in San Diego. If this is your first time reading my blog, please note that I am not a doctor. If you have medical questions please contact your own doctor or better yet find a Defeat Autism Doctor! (DAN!) in your area so they can fully explain and/or implement the protocol for your child and their needs. Again, I am not a doctor and I am not dispensing medical advice.
To help digestive issues you must first – Clear the Decks!
get rid of junk food, impure water, food with artificial colors and flavors, scented products, be careful of laundy products, no cigarette smoke, fumes from the garage and sprays, volatile yard/garden chemicals.
Overview of Food Issues
. Fats, carbs and proteins are digested differently.
. ASD individuals can have problems with all three.
. Maldigestion can lead to –
nutritional deficits
increased allergic responses to foods
dysbiosis and immunologic responses
pain and inflammation
increased mucosal permeability
uptake of toxins and false neurotransmitters
metabolic disorder
Food Reactivity Issues
specific food allergies (IgE, IgG-mediated) can be assessed by lab or dermal testing.
Metabolic problems are harder to identify
– toxin uptake from dysbiotic flora
– peptide and/or toxin binding to active enzyme or transport sites
– undigested food tying up nutrients, or nutrient deficiency allowing increased toxicant uptake.
Subgroups of autistics have measured deficiencies in food digestion
– activity of a peptidase, “DPP4” responsible for digestion of many opiate-like peptides
– activity of enzymes that process starch and complex sugars, esp disaccharidases
– activity of lipase: fat to fatty acids or glycerol
DPP4 = Dipeptidylpeptidase IV = CD26 = Adenosine Deaminase Binding Protein
– Digests B-casomorphins, morphiceptin, gliadinomorphin
– lymphocyte receptor involved in signal transmission
– assists ADA in processing adenosine
– impaired by : Hg, Pb, Cd, too much Zn, milk allergy, organophosphates, streptokinase
stopping here, will finish later.
